ea0047oc31 | Spotlight on Prostate Cancer | Theranostics2016
Hofman Michael S.
, Eu Peter
, Mitchell Catherine
, Blower Phil
, Iravani Amir
, Murphy Declan
, Young Jennifer
, Hicks Rod J.
, Mullen Gregory E.
Ga-68 labelled urea-based inhibitors of the prostate specific membrane antigen (PSMA), such as 68Ga-HBED-PSMA-11, are promising peptides for targeting prostate cancer. The tris(hydroxypyridinone) (THP) ligand rapidly complexes 68Ga3+ at room temperature, at very low concentration and over a wide pH range, making it possible for the direct elution from a 68Ge/68Ga generator into a cold radiopharmaceutical kit in one step wi...