Searchable abstracts of presentations at key conferences in endocrinology

ea0047oc31 | Spotlight on Prostate Cancer | Theranostics2016

First in-man study of 68Ga-THP-PSMA PET in patients with primary prostate cancer: initial results

Hofman Michael S. , Eu Peter , Mitchell Catherine , Blower Phil , Iravani Amir , Murphy Declan , Young Jennifer , Hicks Rod J. , Mullen Gregory E.

Ga-68 labelled urea-based inhibitors of the prostate specific membrane antigen (PSMA), such as 68Ga-HBED-PSMA-11, are promising peptides for targeting prostate cancer. The tris(hydroxypyridinone) (THP) ligand rapidly complexes 68Ga3+ at room temperature, at very low concentration and over a wide pH range, making it possible for the direct elution from a 68Ge/68Ga generator into a cold radiopharmaceutical kit in one step wi...